Localization of CS and Non-CS Antigens in the Sporogonic Stages of Plasmodium Yoelii
Abstract
Charoenvit and associates produced monoclonal antibodies (MAbs) against sporozoites of Plasmodium yoelii. MAbs NYS1, NYS2, and NYS3 recognized the CS antigen, although each reacts with a different epitope. The remaining 2 MAbs, NYS4 and NYS5, recognized antigens which are not CS protein. The antigen recognized by NYS4 is a 140kDa protein (relative molecular mass, M 140000) with a common determinant with the CS protein. The antigen recognized by NYS5 could not be found by Western blotting. Immunofluorescent microscopy (IFA) demonstrated that 3 MAbs (NYS1, NYS2, and NYS3) reacted with the sporozoite surface, although there were slight differences in patterns of reactivity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA235905
Entities
People
- C. T. Atkinson
- L. M. Beaudoin
- M. Aikawa
- M. Sedegah
- R. Beaudoin
- Y. Charoenvit
Organizations
- Naval Medical Research Center