Receptor Binding and Membrane Transport of Botulinum Toxins
Abstract
These studies seek to better understand the mechanism of action of the botulinum toxins. Through the use of antibodies to a number of different membrane-active proteins, any cross-reactivity found between the botulinum toxin protein and other toxin molecules could point to similarities in either structure or function. This similarity could be found in any of the generalized functions of all these toxins: (i) the enzymatic or toxic unit, (ii) the membrane inserting or translocating domain, and (iii) the receptor binding domain. As the protein sequences between these diverse proteins is not known to contain any direct analogies (and all the protein sequences have not been defined) and no direct antigenic cross-reactivities during the action of the toxin molecules bound to ar acting upon artificial target cells (liposomes).
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1990
- Accession Number
- ADA236004
Entities
People
- John R. Dankert
Organizations
- University of Florida