Prophylactic and Treatment Drugs for Organophosphorus Poisoning

Abstract

The program was directed at the design and synthesis of treatment and prophylactic drugs as potential defenses against organophosphorus poisoning. During the past 5.5-year period, 81 compounds were submitted; 20 organophosphonates, 13 carbamates, 12 2-oxo-1,3,2-dioxaphosphorinanes, 7 oximes, 4 organophosphonates, one organophosphate, one phosphonothioate, one phosphinothioate, 4 alkythiosulfonic acids, 2 chloroalkyl (aryl) carboxylic acids, suberyldicholine, and 15 other organic compounds.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1991
Accession Number
ADA236238

Entities

People

  • B. S. Ross
  • C. C. Tseng
  • C. L. Parks
  • P. Blumbergs
  • P. L. Knutson

Tags

DTIC Thesaurus Topics

  • Acids
  • Alcohols
  • Alkenes
  • Amines
  • Benzoic Acids
  • Biomedical Research
  • Carbamates
  • Carboxylic Acids
  • Chemical Reactants
  • Chlorides
  • Contracts
  • Esters
  • Hydrogen
  • Ion Exchange Resins
  • Organophosphorus Compounds
  • Poisoning
  • Sodium Hydroxide

Fields of Study

  • Agricultural and Food sciences
  • Chemistry

Readers

  • Neurotoxicology
  • Organic Chemistry