Bacteria-Phagocyte Interactions: Emerging Tactics in an Ancient Rivalry
Abstract
Although phagocytes appear to have a redundancy of both oxidative and non-oxidative killing mechanism, nevertheless, bacterial pathogens are still able to evade these defenses in vivo and cause lethal infection. As the mechanisms by which phagocytes function have become detailed at the molecular level, both the recognition of specific bacterial virulence determinants and their effects at specific sites in the phagocyte are also being identified. Knowledge of these interactions may permit the use of immunomodulators either to neutralize theses virulence determinants or to enhance the bactericidal capabilities of the phagocyte.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA236325
Entities
People
- Alan S. Cross
- Niamh M. Kelly
Organizations
- Walter Reed Army Institute of Research