Acute Toxicity Evaluation of Nitroaromatic Compounds

Abstract

The nitroaromatics 1,3-dinitrobenzene (DNB), 1,2,5-trinitrobenaene (TNB) and N-methyl-n,2,4,6-tetranitroaniline (tetryl) have been detected as environmental contaminants of water and soil near production waste sites and at military test grounds. Acute toxicity evaluations were carried out with these compounds to develop environmental and health effects criteria. Dermal and eye irritation tests and acute dermal sensitization (Buehler) tests in guinea pigs were conducted according to EPA standard protocols. The sensitization tests showed that DNB and tetryl are not skin sensitizers while TNB caused a mild allergic reaction. None of these compounds produced skin irritation but positive (DNB) to severe (TNB, tetryl) eye irritation potentials were observed.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1991
Accession Number
ADA236352

Entities

People

  • Amy Austin
  • George B. Fitzgerald
  • Nancy Diguilio

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biological Staining And Labeling
  • Biomedical Research
  • Body Weight
  • Health
  • Laboratory Animals
  • Laser Dyes
  • Liquid Chromatography
  • Materials
  • Movement Disorders
  • Range Finding
  • Rodents
  • Skin Diseases
  • Sodium Compounds
  • Standards
  • Test And Evaluation
  • Tissues
  • Toxicity

Readers

  • Agricultural Chemistry/Soil Science
  • Toxicology/Environmental Toxicology