Lipid Dependent Mechanisms of Protein Pump Activity
Abstract
The overall objectives of the contract were to investigate the relationship between the activity of membrane proteins, such as protein pumps and channels, and the elastic curvature properties of the imbedding lipid bilayer. The goal was to understand if lipid composition modulates the protein activity via a coupling to the lipid monolayer elastic energies. This involved investigation both of the physical properties of lipid systems and measurements of the effects upon specific proteins. Progress on the following specific objectives are summarized: (1) The develop techniques for measuring lipid curvature elastic properties. (2) To investigate if the bilayer spontaneous curvature is regulated in bacterial cells. (3) To correlate ion-pump and channel activity with the spontaneous curvature.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 24, 1991
- Accession Number
- ADA236426
Entities
People
- Sol M. Gruner
Organizations
- Princeton University