Piezoelectric Metal Biosensors
Abstract
We have investigated the response of 10 MHz AT-cut Ag electroded piezoelectric crystals to aqueous NaCl solutions (concentration 0.5 to 1.0 mM) and found that the frequency change is linear in this region. We have also investigated the response of these crystals to 4.0 mM solutions of LiCl, NaCl, KCl, RbCl, and CsCl. The alteration of the alkali cation has an effect on the delta f such that the greatest change is for the RbCl and CsCl. Our results suggest that the response of the crystal may be a function of the size of the hydrated cation. 2) We have begun our investigation of the synthesis of cation selective receptor species suitable for attachment to the surface of a piezoelectric crystal. We have prepared three macrocyclic precursors which possess a secondary amine group suitable for further synthetic elaboration. The attachment of long alkyl chains (C22H45-) has been achieved for two of these macrocycles and studies to investigate the deposition of thin films (monolayers) of the receptors using Langmuir-Blodgett techniques are in progress. Silane derivatives of these macrocycles have been prepared by attaching C16 chains possessing a pendant -HC=CH2 moiety.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1990
- Accession Number
- ADA236778
Entities
People
- C. J. Hawkins
- K. N. Raymond
- L. R. Gahan
Organizations
- University of California, Berkeley