New Approaches to Hepatitis A Vaccine Development

Abstract

Hepatitis A virus (HAV) has historically been an important cause of morbidity among U.S. soldiers in the field. Work under this contract is directed at the development of a safe, inexpensive and effective hepatitis A vaccine for use in military personnel. Two main research approaches are under investigation. First, we are characterizing neutralization escape mutants of HAV and examining synthetic oligopeptides representing the suspected surface structures of HAV. Octapeptides have been synthesized on polyethelene pins and probed with polyclonal and monoclonal antibodies in an effort to identify antigenic and potentially immunogenic sequences. We have also determined the ability of poliovirus-HAV chimeric viruses to elicit neutralizing antibodies to HAV.

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Document Details

Document Type
Technical Report
Publication Date
Apr 22, 1991
Accession Number
ADA237161

Entities

People

  • Stanley M. Lemon

Organizations

  • University of North Carolina at Chapel Hill

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acids
  • Antibodies
  • Antigens
  • Biomedical And Dental Materials
  • Cells
  • Chemical Reactions
  • Culture Techniques
  • Epidemiology
  • Genetic Variation
  • Genetics
  • Hepatitis
  • Immune Serums
  • Immunoglobulins
  • Medical Personnel
  • Nucleic Acids
  • Proteins
  • Vaccines

Readers

  • Systems Analysis and Design
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology