Production of Acid-Labile-Alpha Interferon by AIDS Patients
Abstract
Recently, there has been interest in the production of IFNs during the course of HIV infections, and in the possible therapeutic use of IFNs in AIDS-associated Kaposi sarcoma (Krown et al, 1990) or in AIDS. These were the subjects of two meetings held in New York City in 1990, partially on the basis of a report that treatment of clinical AIDS with IFN alpha is effective, and a preliminary report that long-term treatment of HIV carriers prolonged their asymptomatic incubation period (Lane et al, 1990; Rivero et al, 1990). IFNs have a significant inhibitory effects on replication of retroviruses, including lentiviruses (Friedman and Pitha, 1984). Two major mechanisms of action have been identified, both relating to virus assembly: (1) in the case of most murine leukemia viruses (MLVs) and mouse mammary tumor virus, IFN caused an inhibition of virus budding.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1991
- Accession Number
- ADA237252
Entities
People
- Carl W. Dieffenbach
- Robert M. Friedman
- Susana A. Serrate
Organizations
- Uniformed Services University of the Health Sciences