Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis

Abstract

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objectives of this research were the following: (1) To develop a reliable in vitro method for measuring the potential toxicity of promising anti-leismanial drugs on human T4 lymphocytes. (2) To determine if the toxicities of these drugs on T4 cells could be reversed by the addition of nutritional supplements.

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Document Details

Document Type
Technical Report
Publication Date
May 30, 1989
Accession Number
ADA237253

Entities

People

  • Linda L. Nolan

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Antigen-Presenting Cells
  • Blood
  • Cells
  • Chemistry
  • Fungi
  • Health Services
  • Infection
  • Leukocytes
  • Liquid Chromatography
  • Lymphatic System
  • Lymphocytes
  • Metabolism
  • Nucleotides

Fields of Study

  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Parasitology and Pharmacology of Malaria.
  • Systems Analysis and Design