Human Immune Response to HTLV-III Virus Infection in Acquired Immunodeficiency Syndrome
Abstract
This contract was awarded for a three year period to study aspects of the human cellular and humoral antibody responses to HIV-1 infections. The major research findings during this study were: (1) The memory lymphocytes of HIV-1 infected individuals fail to respond to recall viral antigens including HIV-1 antigen early in the course of HIV-1 infections. This finding made aspects of these research investigations extremely difficult especially the study of T cell responses to HIV-1. (2) We generated human CD4+ and CD8+ CTL clones to novel epitopes on the HIV-1 gag protein. (3) We generated a human CD8+ CTL clone to a novel epitope on the envelope glycoprotein gp 160. (4) We established that the sera of HIV-1 infected patients contain antibodies which enhance infection of FcR receptor bearing cells. (5) We demonstrated the antibody dependent enhancement of HIV-1 infection requires two receptors. Fc receptors and CD4.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 28, 1990
- Accession Number
- ADA237303
Entities
People
- Francis A. Ennis
Organizations
- University of Massachusetts