Recognition of All Four Base Pairs of Duplex DNA by Triple Helix Formation. Design of Pyrimidine Specific Bases

Abstract

The novel base 4-(3-benzamido)phenylimidazole was designed, synthesized and incorporated within a pyrimidine oligonucleotide and shown to recognize pyrimidine purine base pairs over purine pyrimidine base pairs. Such specificity allows binding by triple helix formation at an 18 base pairs site in simian virus 40 DNA containing all four base pairs at physiologically relevant conditions.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1991
Accession Number
ADA237360

Entities

People

  • L. C. Griffin
  • Laura Lee Kiessling
  • P. B. Dervan

Organizations

  • California Institute of Technology

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Availability
  • California
  • Chemical Compounds
  • Chemical Engineering
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Identification
  • Military Research
  • Procurement
  • Pyrimidines
  • Recognition
  • Security
  • United States
  • United States Government

Fields of Study

  • Chemistry

Readers

  • Molecular Genetics