Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 1. Executive Summary/Introduction

Abstract

Physiologically-based pharmacokinetic (PBPK) modeling as a risk assessment tool is sensitive to uncertainties and variation in model parameters. This volume summarizes the approaches taken to (1) describe the construction of PBPK models for trichloroethylene, tetrachloroethylene, methylchloroform and vinyl chloride and (2) study the uncertainty associated with PBPK models and model parameters. Also discussed in this volume is the methodology involved with risk assessment software development and execution of a sensitivity/uncertainty analysis.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1990
Accession Number
ADA237365

Tags

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Alkenes
  • Biological Sciences
  • Biomedical Research
  • Cells
  • Chemistry
  • Chlorides
  • Computer Programs
  • Computers
  • Contracts
  • Corporations
  • Kinetics
  • Metabolic Pathways
  • Metabolism
  • Risk
  • Standards

Fields of Study

  • Chemistry

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  • Computational Modeling and Simulation
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