Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 2. Trichloroethylene

Abstract

This volume describes the design, development and execution of physiologically based pharmacokinetic modeling as they apply to trichloroethylene (TCE) exposure in humans. Emphasis is also on TCE metabolites, trichloroacetic acid (TCA). PBPK human models for TCE risk assessment provided a basis for interspecies comparisons and a basis for cancer risk assessment. Trichloroethylene (TCE) are of interest because of recent studies showing TCE to be carcinogenic to rodents. Mice exposed to TCE by inhalation and via gavage developed hepatocellular tumors while rats exposed orally developed kidney tumors. A major metabolite of TCE, trichloroacetic acid (TCA), and a minor metabolite, dichloroacetic acid (DCA), have also been shown to cause hepatocellular tumors in mice when administered in drinking water.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1990
Accession Number
ADA237366

Tags

DTIC Thesaurus Topics

  • Alkenes
  • Biomedical Research
  • Cells
  • Cellular Structures
  • Chemistry
  • Chlorides
  • Chlorinated Hydrocarbons
  • Computer Programs
  • Contracts
  • Cysteine
  • Digestive System Processes
  • Hydrocarbons
  • Metabolic Pathways
  • Metabolism
  • Risk
  • Risk Analysis
  • Standards

Fields of Study

  • Chemistry
  • Environmental science

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  • Software Engineering.
  • Toxicology/Environmental Toxicology