Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 3. Tetrachloroethylene

Abstract

Perchloroethylene (PCE) is a chemical of relevance to the Air Force Installation Restoration Program (IRP) efforts. Pharmacokinetics of PCE and available PCE PBPK were reviewed and a preliminary risk assessment was prepared. Physiologically based pharmacokinetic (PBPK) models developed for PCE were used to examine the behavior of PCE in mice and humans. Uncertainty analysis was applied to the PBPK models used in the risk assessment study. Tetrachloroethylene (PERC) is a commercially important chemical used as solvents. PERC is also a frequent contaminant of drinking water supplies.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1990
Accession Number
ADA237367

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  • Air Force Facilities
  • Alkenes
  • Biomedical Research
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  • Drinking Water
  • Enzyme Kinetics
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Fields of Study

  • Chemistry
  • Environmental science

Readers

  • Aviation Safety Risk Assessment.
  • Computational Modeling and Simulation
  • Groundwater Contamination Remediation.