Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 4. Methylchloroform
Abstract
Physiologically-based pharmacokinetic (PBPK) models were developed and exercised to describe the behavior of methyl chloroform (MC) in mice and humans. Methyl Chloroform was compared to trichloroethylene and perchloroethylene work described in volumes 2 and 3. The models were then applied to risk assessment aspects of MC exposure. The pharmacokinetic work presented here extends the physiologically based pharmacokinetic (PBPK) models of MC that have been proposed to include prediction of TCA plasma concentrations and/or TCA urinary excretion.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1990
- Accession Number
- ADA237368