Development and Validation of Methods for Applying Pharmacokinetic Data in Risk Assessment. Volume 7. PBPK SIM
Abstract
Operating instructions for the use of the software provided (PBPK SIM) are outlined and explained. PBPK SIM procedures for installation, data entry, execution and interpretation are described. Topics also discussed are command files and applicable statistical considerations. PBPK SIM is a software package that combines physiologically based pharmacokinetic (PBPK) modeling and dose-response modeling capabilities in the context of Monte Carlo simulation and uncertainty analysis. The purpose of PBPK SIM is to allow the user to investigate the effects on model output of uncertainty or variability in input parameter values. It is accessed through a user friendly windowed environment that prompts the user for commands. PBPK SIM is linked to PBPK models defined through the software package called ACSL. The link is through data files, created through PBPK SIM, that in turn create command files. When more than one model simulation is run, the input parameters to the PBPK model are allowed to vary. That variation is also defined in the data files, through certain probability distributions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1990
- Accession Number
- ADA237371