Cellular and Tissue Injury during Nonfreezing Cold Injury and Frostbite
Abstract
Our early efforts on this contract have been devoted to developing key assays and establishing initial model systems for testing. Below we outline the preliminary results of studies testing the effects of stresses encountered during nonfreezing cold injury (e.g., low temperature, acidosis, anoxia, elevated inorganic phosphate levels, and intracellular ionic imbalance) on the model systems. Once we have established the acute effects, we will then begin to investigate the mechanism(s) of irreversible damage induced by long- term exposure to these conditions. in addition, we will then apply the methodology to other the sensitive cell types that are involved in clod injury.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 31, 1991
- Accession Number
- ADA237393
Entities
People
- John F. Carpenter