New Synthetic Receptor Derived from Bridged Anthracenes
Abstract
The major goal of the present contract was to develop new insights into the forces responsible for the association of organic molecules so often seen in biological systems (e.g., enzyme-substrate, antibody-antigen, neuroreceptor-neurotransmitter interactions). To this end, a series of water- soluble organic molecules with well-defined hydrophobic binding sites was prepared, and the being characteristics of several structures were evaluated. The most significant discovery of the investigations was the demonstration of the importance of the cation-pi (or, alternatively, ion-dipole ) interaction in producing tight, oriented binding of a wide variety of onium type guests. High field NMR was the primary tool used to establish the cation-pi interaction as a potent force for binding in both aqueous and organic media.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 29, 1991
- Accession Number
- ADA237461
Entities
People
- Dennis A. Dougherty
Organizations
- California Institute of Technology