Mouse Hepatitis Virus Infection Suppresses Modulation of Mouse Spleen T- Cell Activation

Abstract

Natural infection by mouse hepatitis virus (MHV) can affect interpretation of immunological studies in mice. MHV, a collective term describing a group of corona viruses, is found in natural infections in over 70 % of laboratory mouse populations in the United States and Canada. Natural outbreaks of mouse hepatitis virus (MHV) in our animal colony afforded us the opportunity to study MHV-induced immunosuppression as well as the effects of MHV infection on neurotransmitter-immunomodulation. Concanavalin A-stimulated DNA synthesis by spleen T-lymphocytes from MHV-infected mice was 20-50 % that of noninfected mice.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA237464

Entities

People

  • Donald A. Chambers
  • Hidayatulla G. Munshi
  • Joan M. Cook-mills
  • Robert L. Perlman

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Albumins
  • B Lymphocytes
  • Blood
  • Cells
  • Chemistry
  • Coronaviruses
  • Diseases And Disorders
  • Immune System
  • Infection
  • Laser Dyes
  • Lymphatic System
  • Lymphocytes
  • Norepinephrine
  • Nucleotides
  • T Lymphocytes
  • Thymocytes
  • Wound Infections

Fields of Study

  • Biology

Readers

  • Immunology
  • Virology (or Medical Virology).