The Involvement of the Immune System in Neuronal Plasticity

Abstract

Damage to the entorhinal afferents to the hippocampal dentate gyrus (i.e. perforant path) leads to sprouting of the remaining intact septal cholinergic afferents within the denervated outer molecular layer. To investigate the cellular and molecular events which contribute to this sprouting response we describe the temporal sequence of cellular changes in the denervated zone prior to the observed neural reorganization. Rats were given perforant path (PP) transections and sacrificed at various time points following the lesion, on Days (D) 1,2,3,4,5,6, and 30. Coronal sections at the level of the dorsal hippocampus were immunostained to localize microglia (OX-42), interleukin (IL-1) and astrocytes (GFAP). We observed a rapid increase in the number of microglia in the denervated molecular layer within the first day following PP transection.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1991
Accession Number
ADA237579

Entities

Organizations

  • University of California, San Diego

Tags

DTIC Thesaurus Topics

  • Brain
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Neurons
  • Neurosciences
  • Peptide Growth Factors
  • Proteins

Fields of Study

  • Biology

Readers

  • Neuroscience