Interactions of Neuromodulators with Cells of the Immune System

Abstract

The long term goal of this project has been to define and explain mechanistically, interactions of the immune system with molecules related to 'biological stress'. During the tenure of this proposal, we demonstrated that norepinephrine (NE) can inhibit both T and B cell activation by mitogens, antigen, and interleukin 2. The use of a clonally derived T cell lymphoma, the S49 cell, and S49 cell mutants unable to synthesize cyclic AMP (AdCy) or utilize the cyclic AMP-dependent protein kinase (PKA) revealed that NE effects required the presence of a functioning cyclic AMP/protein kinase A system. Examination of the NE-mediated down regulation of the Thy-1 gene revealed that NE modulation occurs at mRNA transcription and requires the presence of a functional cyclic AMP protein kinase.

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Document Details

Document Type
Technical Report
Publication Date
Jun 20, 1991
Accession Number
ADA237613

Entities

People

  • Donald A. Chambers

Organizations

  • University of Illinois at Chicago

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antigens
  • B Lymphocytes
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Immune System
  • Lymphatic System
  • Lymphocytes
  • Neoplasms
  • Nervous System
  • Nucleotides
  • T Lymphocytes
  • Thymocytes
  • Tumor Cell Line

Fields of Study

  • Biology

Readers

  • Cellular and Molecular Pathways of Apoptosis.
  • Neuroscience

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech