Investigation of the Hepatotoxic and Immunotoxic Effects of the Peroxisome Proliferator Perfluorodecanoic Acid
Abstract
Our research efforts of the past six months have involved evaluation of the immunotoxic and toxic effects of perfluorodecanoic acid (PFDA). Eight day exposure to PFDA caused thymic atrophy with marked thymocyte depletion as well as decreased spleen cellularity at 50 mg/kg. Con A-induced T cell mitogenic responses were decreased at 20 mg/kg PFDA, but no effect on B cell proliferation was observed. Antigen-induced proliferation was decreased in both 20 and 50 mg/ kg PFDA-exposed animals, although delayed-type hypersensitivity reactions did not vary significantly from control animals. Interestingly, IL-2 activity of cell culture supernates was increased with PFDA exposure, although NK cell activity was similar to control and lymphocyte subsets (Th and Ts/c cells) were not affected.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 30, 1991
- Accession Number
- ADA237787
Entities
People
- Donald E. Frazier
- Melinda J. Tarr
Organizations
- Ohio State University