Human Immunodeficiency Virus (HIV) Infections: Strain and Type Variations; Diagnosis and Prevention

Abstract

The results show that: (a) the replicative capacity of HIV-2, like HIV-1, correlates with the severity of immunodeficiency; (b) molecular clones of a rapid/high HIV-1 isolate may have restricted replicative capacity compared to the genetically heterogenous isolate. Transfection of the same molecular clones into different cell types may yield progeny viruses with different phenotypes; (c) monocyte tropism is a general property of HIV isolates. In some cases silent infection is established. Silently infected monocyte/macrophages harbor virus that can be recovered by cocultivation with peripheral blood mononuclear cells.

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Document Details

Document Type
Technical Report
Publication Date
Apr 30, 1991
Accession Number
ADA237815

Entities

People

  • Eva M. Fenyo
  • Norrby Erling

Tags

DTIC Thesaurus Topics

  • Antigens
  • Blood
  • Cells
  • Chemical Reactions
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Dna Sequence Analysis
  • Health Services
  • Hiv Infections
  • Immune System
  • Infection
  • Liquid Chromatography
  • Macrophages
  • Monocytes
  • Polymerase Chain Reaction
  • Test Methods

Fields of Study

  • Biology

Readers

  • Immunology
  • Molecular Genetics
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech