Phosphoprotein Regulation of Synaptic Reactivity

Abstract

The regulation of synaptic reactivity by protein kinase C and its substrates has been studied using the long-term potentiation paradigm (LTP). We have studied the effects of protein kinase C activators and inhibitors on behavior: imprinting in the chick and radial arm maze performance. The main conclusion to be drawn is that PKC is necessary but not sufficient for the enhanced durability of memory. In combination with a neural signal, however, PKC demonstrates a profound synergism. Synergism is also observed in the analysis of metal ion regulation of PKC activity. Calcium and zinc interact in their effect on the enzyme in a bidirectional manner. Significant accomplishments made during the period were: determining the effect of inhibitors on behavior and the species generality of PKC-F1 module in memory formation.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1991
Accession Number
ADA237849

Entities

People

  • Aryeh Routtenberg

Organizations

  • Northwestern University

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  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Air Force
  • Alzheimer Disease
  • Biological Sciences
  • Biology
  • Brain
  • Chemistry
  • Illinois
  • Inhibitors
  • Medical Personnel
  • Molecules
  • Nervous System
  • Neurosciences
  • Proteins
  • Reactivities
  • Regulations
  • Scientific Research
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Fields of Study

  • Biology

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