Heterosynaptic Modulation of Long-Term Potentiation at Mossy Fiber Synapses in Hippocampus

Abstract

The overall goal of this research project was to investigate the cellular and membrane mechanism associated with heterosynaptic modulation of long-term synaptic potentiation (LTP) at mossy fiber synapses in the hippocampus. Previous work in this laboratory had shown that norepinephrine (NE) , through Beta-adrenoceptors, enhances the magnitude, duration, and probability of induction of mossy fiber LTP. We also had preliminary evidence that acetylcholine (ACh), through muscarinic reporters, depresses the magnitude and probability of induction of mossy fiber LTP. We hypothesized that the heterosynaptic modulation of mossy fiber LTP was through modulation of voltage- gated calcium channels. That is, the modulation of LTP by NE results from an enhancement of voltage-gated calcium channels, while suppression of LTP by ACh was through a decrease in activity of voltage-gated calcium channels.

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Document Details

Document Type
Technical Report
Publication Date
May 31, 1991
Accession Number
ADA238027

Entities

People

  • Daniel Johnston

Organizations

  • Baylor College of Medicine

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  • Norepinephrine
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  • Biology

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