Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis

Abstract

Leishmaniasis, a disease caused by protozoan parasites of the Lesihsmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment for leishmaniasis. The objective of this research was to isolate and characterize unique leishmanial enzymes (DNA polymerase and S- adenosylsynthetase) for the purpose of chemotherapeutic exploitation.

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Document Details

Document Type
Technical Report
Publication Date
May 29, 1991
Accession Number
ADA238236

Entities

People

  • Linda L. Nolan

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Albumins
  • Alcohols
  • Animals
  • Biomedical And Dental Materials
  • Carrier Proteins
  • Cells
  • Chemistry
  • Classification
  • Enzyme Inhibitors
  • Enzyme Kinetics
  • Eukaryotes
  • Fatty Acids
  • Massachusetts
  • Materials
  • Nucleotides
  • Polymeric Films
  • Protozoa

Fields of Study

  • Medicine

Readers

  • Molecular Genetics
  • Parasitology and Pharmacology of Malaria.