LPI845 Liquid Gun Propellant Dermal Toxicity Studies. An Assessment of the LP1846 Utilizing the Mammalian Cell Cytogenetics Assay With Chinese Hamster Ovary (CHO) Cells
Abstract
SRI International assessed the ability of LP1846 to induce chromosomal aberrations (CA) in Chinese hamster ovary (CHO) cells both in the presence and absence of rat S-9 metabolic activation enzymes (MA). In the definitive studies in the absence of MA, CHO cells exposed to LP1846 at concentrations of 62.5, 125.0 and 250.0 microgram/ml with an 8- to 10-hour harvest were evaluated microscopically for mitotic indices and for chromosomal aberrations. In the presence of MA, CHO cels exposed to LP1846 concentrations of 625.0, 1250.0, and 2500.0 microgram/ml with an 8- to 10-hour harvest were evaluated microscopically for mitotic indices and for chromosomal aberrations. Vehicle and positive controls were included in the study. On this basis of our criteria for interpretation, we conclude that LP1846 induces chromosomal aberrations in the presence bt not in the absence of MA under the conditions used in this study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1990
- Accession Number
- ADA238250
Entities
Organizations
- SRI International