The Screening and Evaluation of Experimental Antiparasitic Drugs
Abstract
Malaria chemotherapeutic studies included a primary antimalarial blood schizontocidal test system (MM test), where 1,500 compounds were evaluated against Plasmodium berghei with 327 exhibiting activity, and a secondary antimalarial program consisting of in depth evaluation of compounds against drug-sensitive and drug-resistant lines. In a 3-dose modified MM test artelinic acid exhibited better activity than 5 analogs of artemisinin and only 2 of the 4 different 5-fluoropyrimidine analogs were active. Neither verapamil, diltiazem, nor prochloroperazine reversed chloroquine resistance in a highly chloroquine- resistant line even when mice were pretreated with phenylhydrazine. The antimalarial activity of primaquine, dapsone, and menocotone was hindered when mice received phenylhydrazine. Alloxan did not influence the antimalarial activity of several compounds. FeSO4 but not CuSO4 enhanced the activity of WR181023. Peroxidized cod-liver oil and menhaden oil had antimalarial activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1990
- Accession Number
- ADA238552
Entities
People
- Arba L. Ager Jr.
Organizations
- University of Miami