Models of Excitation-Secretion Coupling in Pituitary Cells
Abstract
This report describes final studies in developing a biophysical description of the electrical events surrounding hormone release in pituitary cells. Utilizing a model based on a membrane capacitance shunted by potassium and calcium channels, we are developing a computer program that will simulate the dynamic response of the transmembrane potential of GH3 cells in response to thyrotropia-releasing hormone (TRH). When available, we are using published channel models of potassium and calcium channels. In parallel, we are presuing a phase-plane description of the electrical properties. These models and analyses will be used to investigate effect of temperature on membrane action potentials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 26, 1991
- Accession Number
- ADA238594
Entities
People
- Frank Starmer
Organizations
- Duke University Hospital