Chemotherapy and Drug Targeting in the Treatment of Leishmaniasis

Abstract

Leishmaniasis, a disease caused by protozoan parasites of the Leishmania spp., is one of the major public health problems currently affecting humanity. Therapeutic agents for this disease is either ineffective or toxic. The purpose of this work is to aid in the development of an effective, non-toxic treatment of leishmaniasis. The objectives of this research are the following: (1) To isolate and characterize unique leishmanial enzymes (DNA polymerase and S-adenosylsynthetase) for the purpose of chemotherapeutic exploitation; and (2) To test promising analogs both in vivo and in vitro to determine their potential as antileishmanial agents.

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Document Details

Document Type
Technical Report
Publication Date
May 30, 1990
Accession Number
ADA238768

Entities

People

  • Linda L. Nolan

Organizations

  • University of Massachusetts Amherst

Tags

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Eukaryotes
  • Infection
  • Leishmania
  • Leishmaniasis
  • Lymphocytes
  • Nucleotides
  • Organic Chemistry
  • Parasites
  • Protozoa

Fields of Study

  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Parasitology and Pharmacology of Malaria.