Studies of Epstein-Barr Virus Infection and Immunoregulation in Patients with Aids and Aids-Related Disorders

Abstract

The goal of this research effort was to identify the mechanisms responsible for growth of EBV-immortalized B cells and their immune regulation in vivo. In addition, this research sought to define defects of growth and regulation in EBV-infected B cells during HIV infection. Major findings include: (1) identification of two molecules, IL-6 and lactic acid, responsible for autocrine growth stimulation of EBV-immortalized B cells; (2) recognition of a novel regulatory mechanism responsible for growth regulation of EBV-immortalized B cells where T cells deplete growth factors required by EBV-immortalized B cells for growth and 3) identification of abnormal serum IL-6 concentrations in HIV-infected individuals and demonstration of IL-6 tumorigenicity for EBV- immortalized B cells.

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Document Details

Document Type
Technical Report
Publication Date
May 02, 1991
Accession Number
ADA238805

Entities

People

  • Giovanna Tosato

Organizations

  • Food and Drug Administration

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Acquired Immune Deficiency Syndrome
  • B Lymphocytes
  • Blood
  • Cancer
  • Cells
  • Chemistry
  • Culture Techniques
  • Cytokines
  • Diseases And Disorders
  • Hiv Infections
  • Infection
  • Lactic Acid
  • Lymphocytes
  • Materials
  • Medical Personnel
  • Neoplasms
  • T Lymphocytes

Fields of Study

  • Biology

Readers

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  • Immunology
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