Quantitative Study of Wound Infection in Irradiated Mice
Abstract
Bacterial infection of simple wounds was studied directly and quantitatively in adult mice given 6.5 Gy Co. Three days later, when neutropenia was evident, the skin and the medial gluteus muscle of anaesthetized mice were incised. A suspension of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae or Streptococcus pyogenes was inoculated into the wound. Bacteria per mg muscle were enumerated 3, 4 or 7 days later. The geometric means of bacteria per mg were greater in irradiated than in non-irradiated mice. Phagocytic cells were present in the wounded tissue. Hence sublethal ionizing radiation enhanced the susceptibility of mice to infections of wounds by these four bacterial species.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA238921
Entities
People
- I. Brook
- S. M. Stiefel
- T. B. Elliott
Organizations
- Armed Forces Radiobiology Research Institute