Administration of Interleukin-6 Stimulates Multilineage Hematopoiesis and Accelerates Recovery from Radiation-Induced Hematopoietic Depression

Abstract

Hematopoietic depression and subsequent susceptibility to potentially lethal opportunistic infections are well-documented phenomena following radiotherapy. Methods to therapeutically mitigate radiation-induced myelosuppression could offer great clinical value. In vivo studies in our laboratory have demonstrated that interleukin-6 (lL-6) stimulates pluripotent hematopoietic stem cell (CFU-s), granulocyte-macrophage progenitor cell (GM-CFC) , and erythroid progenitor cell (CFU-e) proliferation in normal mice. Based on these results, the ability of lL-6 to stimulate hematopoietic regeneration following radiation-induced hematopoietic injury was also evaluated.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1991
Accession Number
ADA238944

Entities

People

  • G. N. Schwartz
  • J. L. Williams
  • L. M. Souza
  • M. L. Patchen
  • T. J. Macvittie

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Blood
  • Blood Cells
  • Blood Coagulation
  • Bone Marrow Cells
  • Cell Physiological Processes
  • Cells
  • Central Processing Units
  • Granulocytes
  • Growth Factors
  • Hematopoiesis
  • Hemorrhage
  • Lymphatic System
  • Lymphocytes
  • Macrophages
  • Proteins
  • Stem Cells
  • Three Dimensional

Fields of Study

  • Medicine

Readers

  • Immunology and Pathology
  • Oncology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech