Inhalation Toxicity of Single Materials and Mixtures. Phase 2.
Abstract
A four-week inhalation toxicity study to aerosols of graphite particles in male and female F344/N rats was conducted to evaluate the effects of exposure concentration, daily duration, weekly frequency and sex of the animals on selected biologic endpoint parameters including pulmonary lavage, pulmonary function, lung weights, histopathology and clinical pathology. Endpoints were evaluated after the last exposure and after a two-week recovery period. In addition, all animals were monitored throughout the study for clinical signs, body weights, and selected groups for food consumption. A fractional factorial design, which allows for the most efficient use of the experimental resources, and multivariate analysis of variance models were used for the statistical evaluation of these studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 29, 1991
- Accession Number
- ADA239009
Entities
People
- Catherine Aranyi
Organizations
- IIT Research Institute