Laser Induced Retinal Injuries

Abstract

In our previous study we have shown that the ocular response to laser induced ocular injury is characterized by an inflammatory reaction with enhancement in prostaglandin (PG) production and a cellular infiltration. Steroid treatment curtailed the PGs response but did not effect the inflammatory infiltrate. In the present study, we investigated the involvement of leukotrienes B4 (LTB4) in laser induced retinal injury. The following parameters were studied; LTB4 production by the retinachoroid, its accumulation in the vitreous, and changes in vitreal protein levels.. In addition, the effect of an antileukotriene drug (NDGA) on LTB4 accumulation in the vitreous was studied. Histopathological evaluation of the inflammatory response following NDGA treatment alone or combined with steroids was performed well. The antileukotriene drug that has been chosen for the present study was norguaiaretic acid.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1991
Accession Number
ADA239046

Entities

People

  • Michael Belkin
  • N. Naveh

Organizations

  • Tel Aviv University

Tags

DTIC Thesaurus Topics

  • Adhesion
  • Biological Pigments
  • Blood
  • Blood Vessels
  • Body Weight
  • Cells
  • Elements
  • Energy Levels
  • Epithelium
  • Eye
  • Laboratory Animals
  • Laser Applications
  • Laser Safety
  • Materials
  • Pilot Studies
  • Uvea
  • Yag Lasers

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology and Pathology
  • Vision Science/Vision Psychology/Cognitive Neuroscience.

Technology Areas

  • Directed Energy