Antisense Oligodeoxynucleotide Inhibition of HIV Gene Expression
Abstract
The goal of this work is to develop novel, efficacious, injectable, gene-specific therapeutics for treatment of human immunodeficiency virus (HIV) infection. These products will be nuclease resistant, stereospecific antisense inhibitors of human immunodeficiency virus gene expression and activity. Antisense DNA inhibition has worked in this laboratory against several human and viral genes in cell culture. In this project, routes are being developed for the stereospecific synthesis and purification of all-S or all-R oligodeoxynucleoside methylphosphonates directed against specific HIV mRNAs, and against tat protein. Several dimers have been prepared by the pentavalent solution route, and encouraging results have been obtained for the trivalent solution route.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 20, 1989
- Accession Number
- ADA239086
Entities
People
- Eric Wickstrom
Organizations
- University of South Florida