DNA-Mediated Electron Transfer and Application to 'Biochip' Development.

Abstract

To study the electronic properties of double-stranded DNA as to determining whether this macromolecule can support electron transport processes. This pertains to possibly utilizing the base sequence and secondary structure of DNA as a matrix for developing molecular level electronic components. Toward these goals, we have studied the anisotropic electronic properties of DNA single crystals using reflectance spectroscopy and studied the interactions of transitions metals with double-stranded DNA by X-ray diffraction. We have also synthesized a number of porphyrin and acridine modified DNA molecules, and assembled a photoflash photolysis apparatus for direct study of electron transfer through DNA. In related work, we have shown that the propensity for DNA to adopt specific double helical conformations can be predicted from calculations of solvent accessible surfaces. From this, we were able to obtain diffraction quality single crystals of DNA oligomers in a predictive manner.

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Document Details

Document Type
Technical Report
Publication Date
Jul 25, 1991
Accession Number
ADA239093

Entities

People

  • Pui S. Ho

Organizations

  • Oregon State University

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Absorption Spectra
  • Availability
  • Biochemistry
  • Classification
  • Crystal Lattices
  • Crystal Structure
  • Crystals
  • Diffraction
  • Electron Transfer
  • Electrons
  • Macromolecules
  • Security
  • Single Crystals
  • Spectra
  • Transitions
  • Universities
  • X-Ray Diffraction

Fields of Study

  • Chemistry

Readers

  • Chemistry (specifically Chemical Fluorescence)
  • Molecular Genetics
  • Nanofabrication and Microfabrication.

Technology Areas

  • Microelectronics
  • Microelectronics - Graphene