Anti-Cyanide Drugs
Abstract
This report describes our efforts to develop anti-cyanide drugs using simple, water soluble metalloporphyrin molecules. Vanadium (4), chromium (3) molybdenum (5), manganese (3), iron (3), nickel (2), copper (2), silver (3), zinc, indium (3), aluminum, platinum (2), palladium (2), and gold (3) porphyrins had no affinity for cyanide at ph7.2. In vitro work showed cobalt (3), rhodium (3), and ruthenium (2) porphyrins bind cyanide in both the di- and trivalent states, from kinetic, equilibrium and electrochemical studies. Nickel (2) central N-alkyl porphyrins liberate nickel to complex with cyanide and are otherwise stable to nickel loss. sterically hindered porphyrins in the iron (III) form rapidly complex cyanide. The LD-50s of thirteen porphyrins and phthalocyanines are in the 100-600 mg/kg range in rats. None of the cobalt, iron, rhodium or silver porphyrins or phthalocyanines protect mice in a prophylactic fashion against 2 LD-50s of cyanide.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1991
- Accession Number
- ADA239281
Entities
People
- Peter Hambright
Organizations
- Howard University