Feasibility Study of Pharmacological Treatment to Reduce Morbidity and Mortality After Brain Injury

Abstract

The experiments conducted during the three years of this contract and the continued work (until the end of 1990)were very productive. We have made considerable progress toward achieving the goal of developing a pharmacological treatment regimen for promoting functional recovery after traumatic brain injury (TBI). This report summarizes the objectives, results and discusses the significance of published findings as well as several completed being replicated and/or written for publication. The research supported by this contract utilized a multi-disciplinary approach to analyze some effects of pharmacological intervention on functional recovery from locomotor deficits after a unilateral injury to the right sensorimotor cortex (SMCX) in the rat; First, the well documented beneficial effect of a single dose of d-amphetamine (AMPH) on functional recovery after SMCX ablation was extended to different severities of SMSX confusion. Second, the effects of systemic administration of drugs affecting catecholaminergic.

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Document Details

Document Type
Technical Report
Publication Date
Apr 02, 1991
Accession Number
ADA239283

Entities

People

  • Dennis M. Feeney
  • Kurt A. Krobert
  • Michael P. Weisend
  • Susan A. Queen

Organizations

  • University of New Mexico

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Amino Acids
  • Brain
  • Brain Injuries
  • Cell Physiological Processes
  • Central Nervous System
  • Cerebral Cortex
  • Chemistry
  • Contracts
  • Craniocerebral Trauma
  • Feasibility Studies
  • Liquid Chromatography
  • Neurosciences
  • New York
  • Norepinephrine
  • Therapy
  • Wounds And Injuries

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.
  • Technical Research and Report Writing.