Experimental Model for the Study of Periodontal Wound Healing
Abstract
To evaluate the influence of biologic mediators on the regenerative capabilities of the periodontium, it is essential to establish a baseline for wound healing events in the absence of disease. The primary goal of this study was to evaluate a fenestration wound healing model. Surgically created defects were made into the dentin through alveolar bone fenestrations at the mid-root level in 8 sites per arch in 4 primates (macaca mulatta). A total of 32 fenestration wound sites were made. Experimental results suggest that the fenestration wound model in a non-human primate has a high propensity for healing and thus may serve as a valuable model for assessing wound healing events. The observation of healing events in the absence of disease provides a predictable model for evaluating optimal effects of various procedures on the healing of periodontium. This model naturally excludes oral epithelium, microbial and hygiene influences and anatomical variables, in addition to maintaining a functional dentition. The lack of dissimilarities in healing with and without exclusion membranes suggests this fenestration wound may be of inadequate size to demonstrate differences in healing during prolonged evaluation times. Larger size defects and/or earlier time periods should be evaluated to determine the influence of potential periodontal treatment modalities on wound healing and to characterize the early events leading to regeneration of the periodontium.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1991
- Accession Number
- ADA239338
Entities
People
- Robert R. Burnett
Organizations
- Air Force Institute of Technology