Muramyl Peptide-Enhanced Sleep: Pharmacological Optimization of Performance

Abstract

It is now recognized that sleep results from neuronal activity which is regulated by the interactions of neurons with substances produced by neurons and other cellular components of the brain. Over the past 30 years, our technical abilities to identify and synthesize biochemicals has greatly improved; these advances have led to the identification of several endogenous sleep factors (SFs) (substances that promote sleep). Over the past five years of this contract, we have identified several new SFs and synthesized analogs that may be developed into new, more effective, and safer somnogenic agents. The broad goal of this USAMRDC-supported work has been to develop the information needed to determine if it is reasonable to propose either endogenous SFs or synthetic analogs as potential sleep-inducing agents for military use.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1991
Accession Number
ADA239442

Entities

People

  • James M. Krueger

Organizations

  • University of Tennessee

Tags

DTIC Thesaurus Topics

  • Blood
  • Brain
  • Cells
  • Chemistry
  • Digestive System Processes
  • Endothelial Cells
  • Epithelial Cells
  • Eye Movements
  • Human Behavior
  • Insulin
  • Lymphocytes
  • Neuroglia
  • Peptide Growth Factors
  • Peptides
  • Pituitary And Hypothalamic Hormones And Analogues
  • Proteins
  • Sleep Deprivation

Readers

  • Molecular and Cellular Biochemistry
  • Neurological Diseases/Conditions/Disorders
  • Neurotrauma and Rehabilitation Medicine.