Comparative Mutagenicity of Urinary Metabolites of Nitropolycylic Aromatic Hydrocarbons 1-Nitropyrene, 2-Nitrofluoranthene, and 3- Nitrofluoranthene

Abstract

This study compared the mutagenicity of urinary metabolites of prevalent air pollutants nitropyrene, nitrofluoranthene, and nitrofluoranthene. Rats were injected intraperitoneally with specific doses and their urine was analyzed for mutagenicity by an Ames plate incorporation assay using Salmonella Typhimurium. Resulting data yielded revertant excretion rate plots used for comparative analysis. To achieve maximum mutagenicity, 1-NP's urinary metabolites required exogenous activation by S9, 2-NFA's did not vary significantly with S9 activation, while 3-NFA's was decreased by S9 metabolism. 2-NFA's mutagenic metabolites' revertant excretion rate was a quarter of the rates of 3-NFA's and 1-NP's mutagenic metabolites. The strongest mutagenicity of urinary metabolites during the 48 hrs after injection was from 1-NP which was double the amounts from 3-NFA and 2-NFA.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1991
Accession Number
ADA239486

Entities

People

  • Michael N. Boucher

Organizations

  • Air Force Institute of Technology

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DTIC Thesaurus Topics

  • Aromatic Hydrocarbons
  • Chemistry
  • Cyclic Hydrocarbons
  • Digestive System Processes
  • Ecology
  • Environment
  • Fossil Fuels
  • Hydrocarbons
  • Kinetics
  • Literature Surveys
  • Materials
  • Metabolism
  • Metabolites
  • Microsomes
  • Neoplasms
  • Nitrogen Oxides
  • Rate Of Formation

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