Fundamental Studies in the Molecular Basis of Laser Induced Retinal Damage.
Abstract
The past three years has seen considerable advancements in our understanding of the fundamental basis of laser interaction with retinal and ocular tissue. In this section we will review our achievements during the past three years of support by the Ocular Hazards Program of the United States Letterman Army Institute of Research. This support has resulted in 15 published papers (see references 1-9 and 14-19 in the Bibliography). These papers have reported for the first time second harmonic generation in rhodopsin. The data provide an understanding of the very efficient second harmonic generation that is occuring in visual pigments. The fundamental understanding that we have obtained begins to elucidate the interactions that could underly the psychophysical phenomena that have been indicated green sensation with Nd:YAG laser illumination. In address, these results are leading to a more detailed understanding of the photodynamics of the rhodopsin spectral alterations under both one and two photon illumination. This photodynamics is the basic information that is required in order to design the constraints that must be met in order to develop photodynamic filters.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1991
- Accession Number
- ADA239941
Entities
People
- Aaron Lewis