TNT Metabolites in Animal Tissues

Abstract

Analyses for TNT and nine potential metabolites (TNT-related compounds) were made in deer, rabbit, and quail tissues (muscle and liver) taken from the Alabama Army Ammunition Plant, Childersburg, Alabama. The listed TNT- related compounds are 2,4,6-trinitrotoluene (parent compound); 2,4-diamino-6- nitrotoluene; 2,6-diamino-4-nitrotoluene;2-amino-4,6-dinitrotoluene;4-amino-2,6- dinitrotoluene;2,4,6-trinitrobenzyl alcohol;2,4,6-trinitrobenzoic acid; 1,3,5- trinitrobenzene; 4-hydroxylamino-2,6-dinitrotoluene; and 2,6,2',6'-tetranitro-4, 4'-azoxytoluene. The procedure for extraction of these compounds from animal tissue required homogenization in acetonitrile, and subsequent partitioning into chloroform. Quantitative analysis of extracted compounds was obtained by chromatographic separation. The main objective of the work was to determine whether TNT and the metabolites were present in the tissues of deer and other game animals at concentrations that would be unsuitable for human consumption.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1991
Accession Number
ADA240080

Entities

People

  • B. A. Thomkins
  • C. -h. Ho
  • C. Guzman
  • Elcin Tan
  • J. E. Caton
  • L. R. Shugart
  • W. H. Griest

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  • Oak Ridge National Laboratory

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  • Biomedical

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