Genetic Toxicity Assessment of Chloropentafluorobenzene
Abstract
Chloropentalfluorobenzene (CPFB), a substituted halogenated benzene, was evaluated in in vitro bioassays to assess its potential genotoxic activity. The assays conducted were the Ames Salmonella/microsomal mutagenicity assay, the Chinese hamster ovary (CHO) gene mutation assay, the CHO/sister chromatid exchange (SCE) and chromosome aberration assay, the BALB/c-3T3 cell transformation assay, and an in vivo/in vitro unscheduled DNA synthesis assay. CPFB did not demonstrate genotoxic potential in any assays with the exception of the SCE assay in the presence of metabolizing enzymes. The skin sensitization and acute inhalation toxicity potential of CPFB has been found to be unremarkable. However, it did produce mild skin and conjunctival irritation in treated rabbits. Repeated inhalation resulted in a reduced rate in growth of rats but not of mice. Histologically the tissue exhibited mild hepatocytomegaly with increased granular eosinophilic cytoplasm. Bone marrow samples from the exposed mice were evaluated for evidence of CPFB induced genetic changes; all findings were negative.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1990
- Accession Number
- ADA240099
Entities
People
- B. C. Myhr
- D. C. Valentine
- R. R. Young
- R. S. Kutzman
- T. E. Lawlor