Effects of a 13-Week Chloropentafluorobenzene Inhalation Exposure of Fischer 344 Rats and B6C3F1 Mice
Abstract
Chloropentafluorobenzene (CPFB) has been indentified as a candidate uptake simulant for nonpersistent chemical warfare agents. Acute toxicity studies have shown that CPFB has limited adverse effects on laboratory animals. A 21-day inhalation study of rats and mice to 2.5, 0.8, and 0.25 mg CPFB/L resulted in reduced weight gain in the high concentration male and female rats only and identified the liver as a potential target organ. In evaluations for its potential to induce chromosomal damage following inhalation exposure, CPFB did not alter the rate of bone marrow cellular proliferation. Assessment of micronucleated polychromatic erythrocyte and non-mochromatic erythrocyte populations during the inhalation exposure indicated a general absence of genotoxic activity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1990
- Accession Number
- ADA240491
Entities
People
- C. D. Flemming
- E. C. Kimmel
- E. R. Kinkead
- H. G. Wall
- S. K. Bunger