Cellular and Tissue Injury during Nonfreezing Cold Injury and Frostbite.

Abstract

We outline further results from studies testing the effects of stresses encountered during nonfreezing cold injury (e.g., low temperature, acidosis, anoxia, elevated inorganic phosphate levels, and intracellular ionic imbalance) on model systems. As we establish the acute effects, we will begin to investigate the mechanism(s) of irreversible damage induced by long-term exposure to these conditions. In addition, we have started to apply the methodology to sensitive cells and formed blood elements that are involved in cold injury.

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Document Details

Document Type
Technical Report
Publication Date
Sep 12, 1991
Accession Number
ADA240619

Entities

People

  • John F. Carpenter

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antifreeze Proteins
  • Antifreezes
  • Biochemistry
  • Blood
  • Cells
  • Chemistry
  • Freezing
  • Glycolysis
  • Heart
  • Heat Energy
  • Low Temperature
  • Molecular Biology
  • Phase Transformations
  • Proteins
  • Skeletal Muscle
  • Transition Temperature
  • Transitions

Readers

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  • Systems Analysis and Design