Screening and Evaluation of Experimental Antiparasitic Drugs.
Abstract
Malaria chemotherapeutic studies in mice included 6 different testing systems. (1) A primary antimalarial blood schizonticidal test (MM) where in 5 years 26,488 compounds were evaluated against Plasmodium berghei with 4,294 exhibiting antimalarial activity. (2) a casual prophylactic test (RP) to detect compounds active against the tissue schizonts where in 5 years over 5,544 compounds were tested with 527 active. (3) A secondary antimalarial test (Ag) were in 5 years over 1,250 compounds were evaluated in a variety of different protocols. Compounds were tested for cross resistance patterns against a battery of drug-resistant parasites. A new line moderately resistant to mefloquine was developed. Resistance to mefloquine, quinine, dapsone, and cycloguanil was retained for at least 42 months while resistance lasted only 9 months to chloroquine and pyrimethamine. Six new synergistic drug was retained for 17 months with 27 of 103 compounds while 2 of 15 were active for 60 days and 4 were inactive for 120 days duration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 19, 1991
- Accession Number
- ADA240647
Entities
People
- Arba L. Ager Jr.
Organizations
- University of Miami