Allopurinol Pretreatment Improves Evoked Response Recovery Following Global Cerebral Ischemia in Dogs.
Abstract
The reperfusion of previously ischemic tissue may lead to the formation of highly reactive free radicals that promote tissue injury. Xanthine oxidase has been implicated as one source of these free radicals. We examined the role of xanthine oxidase in brain injury using a cerebrospinal fluid compression model of global cerebral ischemia with 15 minutes of ischemia and 4 hours of reperfusion. Seven dogs were pretreated with the xanthine oxidase inhibitor allopurinol (50 mg/kg for 5 days). Neurophysiological recovery was monitored with cortical somatosensory evoked potentials. As an attempt to correlate brain recovery with the mechanism of protection, free brain malondialdehyde was measured at the end of reperfusion by high-performance liquid chromatography. Brain water content was measured by wet-dry weights. Compared with seven untreated control dogs, allopurinol pretreatment significantly improved recovery of somatosensory evoked potentials after 4 hours of reperfusion.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1991
- Accession Number
- ADA240815
Entities
People
- Andrew J. Dutka
- John M. Hallenbeck
- Richard B Mink
Organizations
- Naval Medical Research Center